Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.34 |
| ▸ | MTOR | P42345 | 5/20 | 0.34 |
| ▸ | SPR | P35270 | 10/20 | 0.33 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1092603 | 1.00 | CHRM2 (0.37) | CHRM2PIK3CAMTORSPRAVPR1B | |
| SCHEMBL1093150 | 0.86 | PIK3CA (0.37) | CHRM2PIK3CAMTORSPR | |
| SCHEMBL4191597 | 0.86 | ROCK2 (0.34) | CHRM2 | |
| SCHEMBL1093152 | 0.86 | PIK3CA (0.37) | CHRM2PIK3CAMTORSPR | |
| SCHEMBL1091982 | 0.86 | HTR2B (0.34) | SPR | |
| SCHEMBL1091979 | 0.86 | HTR2B (0.34) | SPR | |
| SCHEMBL4345635 | 0.85 | P2RX3 (0.34) | CHRM2SMN1; SMN2 | |
| SCHEMBL4179209 | 0.82 | CHRM2 (0.34) | CHRM2PIK3CAMTORSPRLMNA | |
| SCHEMBL1091733 | 0.77 | LRRK2 (0.35) | — | |
| SCHEMBL1091734 | 0.77 | LRRK2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153807-B2 | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2012-04-10 | — | — | US | disclosed |
| EP-2021336-B1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2010-06-30 | — | — | EP | disclosed |
| US-20090111809-A1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | BUSH JULIE KAY | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111809-A1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | HSD11B1, HSD3B1, HSD11B2 | CHRM2 4381/4885PIK3CA 814/4885MTOR 676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.