Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10919048 | 0.94 | LDHA (0.43) | LDHAALDH1A1KDM4ECYP1A2HPGD | |
| SCHEMBL10913659 | 0.92 | LDHA (0.39) | LDHAFFAR4ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL10910590 | 0.89 | LDHA (0.38) | LDHAFFAR4ALDH1A1CYP1A2CACNA1C | |
| SCHEMBL10921169 | 0.87 | LDHA (0.38) | LDHAALDH1A1KDM4ECYP1A2HPGD | |
| SCHEMBL10913977 | 0.83 | KDM4E (0.42) | ALDH1A1KDM4EHPGDCACNA1CLMNA | |
| SCHEMBL10746812 | 0.81 | ALDH1A1 (0.53) | LDHAALDH1A1KDM4ECYP1A2HPGD | |
| SCHEMBL10913839 | 0.81 | HRH2 (0.40) | ALDH1A1KDM4EHPGDNPC1LMNA | |
| SCHEMBL10922655 | 0.80 | LDHA (0.37) | LDHAALDH1A1CYP1A2CACNA1CCYP2C9 | |
| SCHEMBL10923622 | 0.79 | LDHA (0.39) | LDHAALDH1A1KDM4ECYP1A2HPGD | |
| SCHEMBL10923076 | 0.76 | KDM4E (0.40) | ALDH1A1KDM4ECYP1A2HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0088938-B1 | USE OF PYRIDINE COMPOUNDS FOR THE MANUFACTURE OF MEDICAMENTS WITH AN ANTIHYPOXEMIA AND ISCHEMIA-PROTECTIVE ACTIVITY | BAYER AG (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0088938-A1 | Use of pyridine compounds for the manufacture of medicaments with an antihypoxemia and ischemia-protective activity | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |
| EP-0088940-A1 | Pyridine-carboxylic-acid esters, process for their preparation and their use as pharmaceutical compositions | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |