Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10913091 | 0.93 | MAPT (0.43) | HRH2HRH1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL10911579 | 0.93 | ALDH1A1 (0.39) | HRH2HRH1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL10913633 | 0.90 | LMNA (0.40) | HRH2HRH1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL10911009 | 0.90 | TDP1 (0.39) | HRH2HRH1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL10913623 | 0.86 | KMT2A (0.35) | HRH2HRH1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL10914742 | 0.83 | HRH2 (0.34) | HRH2HRH1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL6959645 | 0.82 | ALDH1A1 (0.44) | ALDH1A1MAPTKDM4ERAB9AGAA | |
| SCHEMBL10913977 | 0.81 | KDM4E (0.42) | ALDH1A1MAPTL3MBTL1KDM4ERAB9A | |
| SCHEMBL10746422 | 0.81 | ALDH1A1 (0.52) | HRH2HRH1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL10926337 | 0.81 | LDHA (0.40) | ALDH1A1MAPTL3MBTL1KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0088940-B1 | PYRIDINE-CARBOXYLIC-ACID ESTERS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BAYER AG (DE) | 1986-05-21 | — | — | EP | disclosed |
| EP-0088938-B1 | USE OF PYRIDINE COMPOUNDS FOR THE MANUFACTURE OF MEDICAMENTS WITH AN ANTIHYPOXEMIA AND ISCHEMIA-PROTECTIVE ACTIVITY | BAYER AG (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0088940-A1 | Pyridine-carboxylic-acid esters, process for their preparation and their use as pharmaceutical compositions | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |
| EP-0088938-A1 | Use of pyridine compounds for the manufacture of medicaments with an antihypoxemia and ischemia-protective activity | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |