Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10913977 | 0.93 | KDM4E (0.42) | KDM4EHSD17B10HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL10914725 | 0.91 | CPB1 (0.36) | KDM4EHSD17B10HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL10913659 | 0.84 | LDHA (0.39) | KDM4EHSD17B10SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL10911579 | 0.83 | ALDH1A1 (0.39) | KDM4EHSD17B10HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL10915061 | 0.82 | PTPN11 (0.41) | CTSA | |
| SCHEMBL10913013 | 0.77 | SMN1; SMN2 (0.34) | SMN1; SMN2MAPTTSHR | |
| SCHEMBL10748805 | 0.77 | CACNB4 (0.46) | KDM4EHSD17B10HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL10926337 | 0.76 | LDHA (0.40) | KDM4EHSD17B10HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL10910590 | 0.75 | LDHA (0.38) | HSD17B10SMN1; SMN2ALDH1A1CYP1A2TSHR | |
| SCHEMBL10913839 | 0.75 | HRH2 (0.40) | KDM4EHPGDRAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0088938-B1 | USE OF PYRIDINE COMPOUNDS FOR THE MANUFACTURE OF MEDICAMENTS WITH AN ANTIHYPOXEMIA AND ISCHEMIA-PROTECTIVE ACTIVITY | BAYER AG (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0088940-A1 | Pyridine-carboxylic-acid esters, process for their preparation and their use as pharmaceutical compositions | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |