Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10925655 | 0.84 | MAPT (0.52) | MAPTLMNARAB9AMAPK1MEN1 | |
| SCHEMBL10926206 | 0.84 | ALDH1A1 (0.43) | MAPTLMNARAB9AMAPK1MEN1 | |
| SCHEMBL10925695 | 0.81 | GSK3B (0.43) | MAPTRAB9AMAPK1MEN1KMT2A | |
| SCHEMBL10925251 | 0.81 | THRB (0.44) | MAPTLMNARAB9AMAPK1MEN1 | |
| SCHEMBL10925057 | 0.80 | ALDH1A1 (0.57) | MAPTRAB9AMAPK1MEN1KMT2A | |
| SCHEMBL6402530 | 0.77 | KMT2A (0.54) | LMNARAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL5243287 | 0.73 | MRGPRX4 (0.51) | MAPTRAB9AMAPK1ALDH1A1HPGD | |
| SCHEMBL1566524 | 0.73 | SMN1; SMN2 (0.63) | MAPTLMNARAB9AKMT2AALDH1A1 | |
| SCHEMBL5591858 | 0.72 | RAB9A (0.65) | MAPTLMNARAB9AMAPK1MEN1 | |
| SCHEMBL18666819 | 0.71 | VNN1 (0.52) | MAPTLMNARAB9AMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189771-A3 | (ISOXAZOL-3-YL)ARYLMETHANONES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-10-08 | — | — | EP | disclosed |
| EP-0189771-A2 | (Isoxazol-3-yl)arylmethanones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-08-06 | — | — | EP | disclosed |
| US-4562187-A | HYPOTENSIVE AGENTS, ANTIINFLAMMATORY, AGENTS, AND ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-31 | — | — | US | disclosed |