Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10927825 | 0.88 | SMN1; SMN2 (0.49) | PDE3BPDE3ASMN1; SMN2LMNAMAPT | |
| SCHEMBL10730668 | 0.78 | PDE3B (0.38) | PDE3BPDE3ASMN1; SMN2LMNAMAPT | |
| SCHEMBL10353452 | 0.76 | SMN1; SMN2 (0.81) | PDE3BPDE3ASMN1; SMN2LMNAMAPT | |
| SCHEMBL10968242 | 0.76 | SMN1; SMN2 (0.38) | PDE3BPDE3ASMN1; SMN2LMNAMAPT | |
| SCHEMBL7304104 | 0.75 | SMN1; SMN2 (0.58) | PDE3BPDE3ASMN1; SMN2LMNAMAPT | |
| SCHEMBL13372830 | 0.74 | TAAR1 (0.80) | SMN1; SMN2LMNACYP2D6TSHRTAAR1 | |
| SCHEMBL7312349 | 0.74 | SMN1; SMN2 (0.62) | PDE3BPDE3ASMN1; SMN2LMNAMAPT | |
| SCHEMBL7304108 | 0.73 | SMN1; SMN2 (0.60) | PDE3BPDE3ASMN1; SMN2LMNAMAPT | |
| SCHEMBL11035016 | 0.72 | SMN1; SMN2 (0.68) | PDE3BPDE3ASMN1; SMN2LMNAMAPT | |
| SCHEMBL7358963 | 0.72 | SMN1; SMN2 (0.58) | PDE3BPDE3ASMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4507298-A | 6-{4-(ω-(1-imidazolyl)-alkyl-phenyl}-3-oxo-2,3,4,5-tetrahydro-pyridazines and acid addition salts thereof, and a process for the treatment of inflammatory, atherosclerotic and thromboembolic illnesses in humans | A. NATTERMANN & CIE GMBH (DE) | 1985-03-26 | — | — | US | claimed |
| EP-0071060-A2 | 6-(4-(Omega-(1-imidazolyl)-alkyl)-phenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazines and their acid-addition salts, process for their preparation and pharmaceutical compounds containing them | A. Nattermann & Cie. GmbH (DE) | 1983-02-09 | — | — | EP | claimed |
| EP-0071060-B1 | 6-(4-(OMEGA-(1-IMIDAZOLYL)-ALKYL)-PHENYL)-3-OXO-2,3,4,5-TETRAHYDRO-PYRIDAZINES AND THEIR ACID-ADDITION SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1986-09-10 | — | — | EP | disclosed |
| US-4507298-A | 6-{4-(ω-(1-imidazolyl)-alkyl-phenyl}-3-oxo-2,3,4,5-tetrahydro-pyridazines and acid addition salts thereof, and a process for the treatment of inflammatory, atherosclerotic and thromboembolic illnesses in humans | A. NATTERMANN & CIE GMBH (DE) | 1985-03-26 | — | — | US | disclosed |
| EP-0071060-A2 | 6-(4-(Omega-(1-imidazolyl)-alkyl)-phenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazines and their acid-addition salts, process for their preparation and pharmaceutical compounds containing them | A. Nattermann & Cie. GmbH (DE) | 1983-02-09 | — | — | EP | disclosed |