Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 6/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 6/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SLC8B1 | Q6J4K2 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3053841 | 0.88 | DDB1 (0.65) | DDB1CRBNMAPTTSHRNPC1 | |
| SCHEMBL8920289 | 0.85 | CRBN (0.50) | DDB1CRBNTP53PRCPNPC1 | |
| SCHEMBL8920781 | 0.85 | CRBN (0.52) | DDB1CRBNPRCPNPC1MAPK13 | |
| SCHEMBL880444 | 0.85 | TP53 (0.59) | TP53MAPTCYP1A2CYP2C9ALOX15 | |
| SCHEMBL8922817 | 0.85 | SLC6A2 (0.51) | DDB1CRBNTP53MAPTCYP1A2 | |
| SCHEMBL8920256 | 0.85 | LMNA (0.54) | DDB1CRBNTP53MAPTCYP1A2 | |
| SCHEMBL8922488 | 0.83 | DDB1 (0.55) | DDB1CRBNTP53MAPTCYP1A2 | |
| SCHEMBL8102823 | 0.82 | DDB1 (0.48) | DDB1CRBNTP53MAPTCYP1A2 | |
| SCHEMBL7827796 | 0.78 | CRBN (0.70) | DDB1CRBN | |
| SCHEMBL8919304 | 0.77 | HTR2A (0.40) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663523-B2 | BET protein-inhibiting 5-aryltriazoleazepines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-05-30 | — | — | US | disclosed |
| EP-2900672-B1 | BET-PROTEIN INHIBITORY 5-ARYL-TRIAZOLO-AZEPINES | Bayer Pharma AG (DE) | 2017-02-22 | — | — | EP | disclosed |
| US-20150299201-A1 | BET PROTEIN-INHIBITING 5-ARYL TRIAZOLE AZEPINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-10-22 | — | — | US | disclosed |
| EP-2900672-A1 | BET PROTEIN-INHIBITING 5-ARYL TRIAZOLE AZEPINES | Bayer Pharma Aktiengesellschaft (DE) | 2015-08-05 | — | — | EP | disclosed |
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299201-A1 | BET PROTEIN-INHIBITING 5-ARYL TRIAZOLE AZEPINES | BRD4, BRDT, BET1 | DDB1 323/4885CRBN 585/4885TP53 851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.