Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ADH1B | P00325 | 1/20 | 0.43 |
| ▸ | ADH1C | P00326 | 1/20 | 0.43 |
| ▸ | ADH1A | P07327 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10435079 | 0.98 | MAPT (0.56) | CYP3A4MAPTKDM4EIDO1MEN1 | |
| SCHEMBL11360130 | 0.79 | IDO1 (0.52) | CYP3A4MAPTKDM4EIDO1MEN1 | |
| Hydrochlorthiazide SCHEMBL28652724 | 0.79 | IDO1 (0.36) | CYP3A4MAPTKDM4EIDO1MEN1 | |
| SCHEMBL19393059 | 0.78 | LOXL2 (0.56) | CYP3A4MAPTKDM4EMEN1KMT2A | |
| SCHEMBL24335030 | 0.76 | ALDH1A1 (0.44) | CYP3A4KDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL24497367 | 0.76 | CYP3A4 (0.48) | CYP3A4MAPTKDM4EIDO1MEN1 | |
| SCHEMBL11151821 | 0.76 | ATM (0.58) | CYP3A4MAPTIDO1MEN1KMT2A | |
| SCHEMBL21034357 | 0.75 | IDO1 (0.48) | CYP3A4MAPTKDM4EIDO1MEN1 | |
| SCHEMBL8075682 | 0.75 | IDO1 (0.54) | CYP3A4MAPTKDM4EIDO1MEN1 | |
| SCHEMBL5355705 | 0.75 | IDO1 (0.48) | CYP3A4MAPTKDM4EIDO1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348369-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-11-02 | — | — | US | disclosed |
| CN-116444454-A | N-hydroxy amidine derivative, preparation method and application thereof, and tumor immunotherapy medicament | 中国医学科学院医药生物技术研究所 | 2023-07-18 | — | — | CN | disclosed |
| US-20230038589-A1 | Methods and compositions for targeting Tregs using CCR8 inhibitors | Nanjing Immunophage Biotech Co., Ltd. (CN) | 2023-02-09 | — | — | US | disclosed |
| US-10730870-B2 | Compounds and methods for the enhanced degradation of targeted proteins | ARVINAS OPERATIONS, INC. (US) | 2020-08-04 | — | — | US | disclosed |
| US-20190092851-A1 | ANTIBODY MOLECULES TO APRIL AND USES THEREOF | Visterra, Inc. | 2019-03-28 | — | — | US | disclosed |
| EP-2424874-A1 | NOVEL PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL ANGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125200-A1 | NOVEL PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL ANGENTS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2010-11-04 | — | — | WO | disclosed |
| WO-2008009076-A2 | SUBSTITUTED PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |
| EP-1608643-A1 | 6-SULFONAMIDE QUINOLINE AND CHROMENE DERIVATIVE AS ANDROGEN RECEPTOR ANTAGONISTS | Warner-Lambert Company LLC (US) | 2005-12-28 | — | — | EP | disclosed |
| US-20050245508-A1 | Treatment of malignant gliomas with TGF-beta inhibitors | SCIOS, INC. (US) | 2005-11-03 | — | — | US | disclosed |
| WO-2004083204-A1 | 6-SULFONAMIDE QUINOLINE AND CHROMENE DERIVATIVE AS ANDROGEN RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-09-30 | — | — | WO | disclosed |
| US-4478833-A | ANTICOAGULANTS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245508-A1 | Treatment of malignant gliomas with TGF-beta inhibitors | TGFBR1, TGFBR2, SMAD3 | CYP3A4 4629/4885MAPT 2319/4885KDM4E 814/4885 |
| US-20230348369-A1 | NAMPT MODULATORS | NAMPT, NNT, NAPRT | CYP3A4 2422/4885MAPT 582/4885KDM4E 2846/4885 |
| US-10730870-B2 | Compounds and methods for the enhanced degradation of targeted proteins | VHL, MDM2, XIAP | CYP3A4 4113/4885MAPT 2786/4885KDM4E 1271/4885 |
| US-20230038589-A1 | Methods and compositions for targeting Tregs using CCR8 inhibitors | CCR8, CCR1, CCR3 | CYP3A4 2832/4885MAPT 4016/4885KDM4E 1941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.