Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10941063 | 0.83 | ALDH1A1 (0.47) | ALDH1A1MAPTNPSR1 | |
| SCHEMBL30880013 | 0.81 | NR4A2 (0.40) | NR4A2AXLCREBBPTSHRLMNA | |
| SCHEMBL1156222 | 0.79 | NR4A2 (0.57) | NR4A2AXLCREBBPTSHRLMNA | |
| SCHEMBL1156693 | 0.78 | NR4A2 (0.52) | NR4A2AXLCREBBPTSHRLMNA | |
| SCHEMBL19064199 | 0.74 | SLC6A4 (0.51) | NR4A2CREBBPTSHRLMNAHTT | |
| SCHEMBL10939265 | 0.73 | TSHR (0.57) | NR4A2CREBBPTSHRLMNAHTT | |
| SCHEMBL10942950 | 0.72 | SMN1; SMN2 (0.57) | NR4A2AXLTSHRLMNASLC6A3 | |
| SCHEMBL26553256 | 0.72 | LMNA (0.48) | NR4A2AXLCREBBPTSHRLMNA | |
| SCHEMBL28000 | 0.71 | TSHR (0.63) | TSHRLMNAHTTSLC6A3ALDH1A1 | |
| SCHEMBL29363206 | 0.71 | TSHR (0.63) | TSHRLMNAHTTSLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |