Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10937622 | 0.83 | NR4A2 (0.49) | ALDH1A1MAPTNPSR1 | |
| SCHEMBL10937546 | 0.78 | AKR1C3 (0.48) | ALDH1A1AKR1C3CDC25BATMKDM4E | |
| SCHEMBL30879998 | 0.77 | AKR1C3 (0.38) | ALDH1A1AKR1C3KDM4ESRD5A2ALOX15 | |
| SCHEMBL27680085 | 0.74 | KDM4E (0.46) | ALDH1A1KDM4EMAPTALOX15PRKAB2 | |
| SCHEMBL28150484 | 0.72 | AKR1C3 (0.64) | ALDH1A1AKR1C3CDC25BATMKDM4E | |
| SCHEMBL19063709 | 0.71 | BCL2L1 (0.44) | ALDH1A1KDM4EPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL10942984 | 0.71 | AKR1C3 (0.48) | ALDH1A1AKR1C3CDC25BATMKDM4E | |
| SCHEMBL15197090 | 0.70 | PBRM1 (0.45) | ALDH1A1AKR1C3ATMKDM4ESRD5A2 | |
| SCHEMBL1923919 | 0.69 | KDM4E (0.37) | ALDH1A1ATMKDM4EMAPTGAA | |
| SCHEMBL10938116 | 0.69 | AKR1C3 (0.65) | ALDH1A1AKR1C3CDC25BATMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |