Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 3/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | BAD | Q92934 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2845134 | 0.90 | KDM4E (0.47) | MEN1KMT2AKDM4EALDH1A1PTGDR2 | |
| SCHEMBL10939339 | 0.85 | MEN1 (0.50) | MEN1KMT2AKDM4EALDH1A1PARP1 | |
| Hydrochloric Acid SCHEMBL10734951 | 0.83 | MEN1 (0.53) | MEN1KMT2ACCR2SOS1USP2 | |
| SCHEMBL1821251 | 0.81 | HTR7 (0.51) | MEN1KMT2AKDM4EPARP1MAPT | |
| SCHEMBL10937671 | 0.81 | MEN1 (0.49) | MEN1KMT2AALDH1A1PARP1PARP2 | |
| Hydrochloric Acid SCHEMBL9486649 | 0.80 | HTR7 (0.50) | MEN1KMT2AKDM4EPARP1MAPT | |
| SCHEMBL10976765 | 0.79 | HTR7 (0.54) | MEN1KMT2AKDM4EPARP1MAPT | |
| SCHEMBL187309 | 0.79 | MEN1 (0.50) | MEN1KMT2AALDH1A1CCR2SOS1 | |
| SCHEMBL10976819 | 0.78 | HTR7 (0.55) | PARP1MAPTHTR7TSHR | |
| Hydrochloric Acid SCHEMBL10936177 | 0.78 | HTR7 (0.53) | MEN1KMT2AKDM4EPARP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0101381-B1 | ANOREXIC TRIFLUOROMETHYL PHENYL TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1985-12-04 | — | — | EP | disclosed |
| US-4521428-A | Anorexigenic trifluoromethylphenyltetrahydropyridines and pharmaceutical compositions containing them | SANOFI (FR) | 1985-06-04 | — | — | US | disclosed |
| EP-0101381-A1 | Anorexic trifluoromethyl phenyl tetrahydropyridines, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1984-02-22 | — | — | EP | disclosed |