Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10933064 | 0.90 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1SMN1; SMN2CCR2 | |
| SCHEMBL10939339 | 0.82 | MEN1 (0.50) | MEN1KMT2AALDH1A1CCR2PARP1 | |
| SCHEMBL9501543 | 0.81 | HTR7 (0.51) | MEN1KMT2APARP1CACNA1BPPARG | |
| SCHEMBL10937656 | 0.81 | MEN1 (0.49) | MEN1KMT2AALDH1A1SMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL10734951 | 0.81 | MEN1 (0.53) | MEN1KMT2AJAK1CCR2PPARG | |
| Hydrochloric Acid SCHEMBL10939473 | 0.80 | HTR7 (0.50) | MEN1KMT2APARP1CACNA1BPPARG | |
| Hydrochloric Acid SCHEMBL9485518 | 0.80 | HTR7 (0.50) | MEN1KMT2APARP1CACNA1BPPARG | |
| SCHEMBL10975429 | 0.79 | HTR7 (0.54) | PARP1CACNA1BPPARGPPARAHTR7 | |
| SCHEMBL187309 | 0.79 | MEN1 (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2CCR2 | |
| Hydrochloric Acid SCHEMBL10938007 | 0.78 | HTR7 (0.53) | PARP1CACNA1BPPARGPPARAHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0101381-B1 | ANOREXIC TRIFLUOROMETHYL PHENYL TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1985-12-04 | — | — | EP | disclosed |
| US-4521428-A | Anorexigenic trifluoromethylphenyltetrahydropyridines and pharmaceutical compositions containing them | SANOFI (FR) | 1985-06-04 | — | — | US | disclosed |
| EP-0101381-A1 | Anorexic trifluoromethyl phenyl tetrahydropyridines, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1984-02-22 | — | — | EP | disclosed |