Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2845133 | 0.91 | MEN1 (0.50) | MEN1KMT2APPARGPPARACCR2 | |
| SCHEMBL10937656 | 0.85 | MEN1 (0.49) | MEN1KMT2APPARGPPARAPARP1 | |
| SCHEMBL8742178 | 0.83 | MEN1 (0.48) | MEN1KMT2APPARGPPARACCR2 | |
| Xaliproden SCHEMBL137094 | 0.82 | SIGMAR1 (0.51) | MEN1KMT2APPARGPPARAPARP1 | |
| Xaliproden SCHEMBL29377982 | 0.82 | SIGMAR1 (0.51) | MEN1KMT2APPARGPPARAPARP1 | |
| SCHEMBL10937671 | 0.82 | MEN1 (0.49) | MEN1KMT2APPARGPPARAPARP1 | |
| Hydrochloric Acid SCHEMBL10734951 | 0.81 | MEN1 (0.53) | MEN1KMT2APPARGPPARACCR2 | |
| SCHEMBL8742167 | 0.81 | PPARG (0.47) | MEN1KMT2APPARGPPARACCR2 | |
| Xaliproden SCHEMBL116721 | 0.81 | SIGMAR1 (0.50) | MEN1KMT2APPARGPPARAPARP1 | |
| Xaliproden SCHEMBL29393004 | 0.81 | SIGMAR1 (0.50) | MEN1KMT2APPARGPPARAPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0101381-B1 | ANOREXIC TRIFLUOROMETHYL PHENYL TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1985-12-04 | — | — | EP | disclosed |
| US-4521428-A | Anorexigenic trifluoromethylphenyltetrahydropyridines and pharmaceutical compositions containing them | SANOFI (FR) | 1985-06-04 | — | — | US | disclosed |
| EP-0101381-A1 | Anorexic trifluoromethyl phenyl tetrahydropyridines, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1984-02-22 | — | — | EP | disclosed |