Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.67 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29190977 | 0.88 | ALDH1A1 (0.76) | ALDH1A1POLBMTNR1AMTNR1BHPGD | |
| SCHEMBL10940167 | 0.83 | HTT (0.68) | ALDH1A1POLBMTNR1AMTNR1BHPGD | |
| SCHEMBL10942225 | 0.82 | ALDH1A1 (0.60) | ALDH1A1POLBMTNR1AMTNR1BHPGD | |
| SCHEMBL10940933 | 0.81 | MAPK14 (0.59) | ALDH1A1POLBMTNR1AMTNR1BHPGD | |
| SCHEMBL10940033 | 0.81 | ALDH1A1 (0.67) | ALDH1A1POLBMTNR1AMTNR1BHPGD | |
| SCHEMBL10939397 | 0.80 | ALDH1A1 (0.58) | ALDH1A1POLBMTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL5537011 | 0.79 | ALDH1A1 (0.56) | ALDH1A1POLBMTNR1AMTNR1BHPGD | |
| SCHEMBL7222358 | 0.77 | ALDH1A1 (0.57) | ALDH1A1POLBMTNR1AMTNR1BHPGD | |
| SCHEMBL29191090 | 0.77 | ALDH1A1 (0.68) | ALDH1A1POLBMTNR1AMTNR1BHPGD | |
| SCHEMBL10938851 | 0.76 | HTT (0.64) | ALDH1A1HPGDL3MBTL1PKMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |