Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29190946 | 0.88 | ALDH1A1 (0.76) | ALDH1A1MAPK14HTTCYP2C9CYP1A2 | |
| SCHEMBL10937651 | 0.84 | ALDH1A1 (0.62) | ALDH1A1MAPK14HTTCYP2C9CYP1A2 | |
| SCHEMBL10939194 | 0.81 | ALDH1A1 (0.67) | ALDH1A1HTTKMT2ALMNAPOLB | |
| SCHEMBL10940933 | 0.81 | MAPK14 (0.59) | ALDH1A1MAPK14HTTKMT2APOLB | |
| SCHEMBL10939397 | 0.80 | ALDH1A1 (0.58) | ALDH1A1HTTCYP2C9KMT2ALMNA | |
| SCHEMBL29191103 | 0.78 | ALDH1A1 (0.70) | ALDH1A1MAPK14HTTCYP2C9CYP1A2 | |
| SCHEMBL27613844 | 0.76 | POLB (0.54) | ALDH1A1MAPK14HTTCYP2C9KMT2A | |
| SCHEMBL10936789 | 0.76 | SRD5A2 (0.58) | ALDH1A1HTTKMT2ALMNANOTUM | |
| SCHEMBL10942146 | 0.75 | POLB (0.54) | ALDH1A1KMT2AMEN1NOTUMPOLB | |
| SCHEMBL2518515 | 0.74 | AKR1C3 (0.61) | ALDH1A1MAPK14HTTCYP2C9MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |