Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.59 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.51 |
| ▸ | DNTT | P04053 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17607058 | 0.88 | MAPK14 (0.67) | MAPK14MAPK7DNTTPOLBALDH1A1 | |
| SCHEMBL29797901 | 0.83 | RAB9A (0.66) | MAPK14MAPK7DNTTALDH1A1GAA | |
| SCHEMBL10937230 | 0.82 | MAPK14 (0.58) | MAPK14MAPK7DNTTPOLBALDH1A1 | |
| SCHEMBL10939194 | 0.81 | ALDH1A1 (0.67) | MAPK7POLBALDH1A1MTNR1AMTNR1B | |
| SCHEMBL10940033 | 0.81 | ALDH1A1 (0.67) | MAPK14POLBALDH1A1MTNR1AMTNR1B | |
| SCHEMBL10939397 | 0.80 | ALDH1A1 (0.58) | MAPK7POLBALDH1A1MTNR1AMTNR1B | |
| SCHEMBL17607099 | 0.77 | MAPK14 (0.64) | MAPK14MAPK7DNTTPOLBALDH1A1 | |
| SCHEMBL1507426 | 0.76 | MAPK14 (0.59) | MAPK14MAPK7POLBALDH1A1MTNR1A | |
| SCHEMBL10944870 | 0.76 | POLB (0.51) | POLBALDH1A1GAARAB9AKMT2A | |
| SCHEMBL10938094 | 0.75 | L3MBTL1 (0.50) | MAPK14MAPK7POLBALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |