Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10938127 | 0.90 | DHODH (0.51) | ALDH1A1MAPTSRD5A2RAB9AGAA | |
| SCHEMBL2419793 | 0.85 | ALDH1A1 (0.68) | ALDH1A1MAPTSRD5A2RAB9AGAA | |
| SCHEMBL10944870 | 0.84 | POLB (0.51) | ALDH1A1SRD5A2RAB9AGAANPC1 | |
| SCHEMBL10938851 | 0.84 | HTT (0.64) | ALDH1A1MAPTSRD5A2RAB9AGAA | |
| SCHEMBL10936789 | 0.84 | SRD5A2 (0.58) | ALDH1A1SRD5A2RAB9AGAANPC1 | |
| SCHEMBL10941754 | 0.83 | ALOX15 (0.51) | ALDH1A1MAPTRAB9AGAANPC1 | |
| SCHEMBL10942146 | 0.83 | POLB (0.54) | ALDH1A1MAPTRAB9AGAANPC1 | |
| SCHEMBL10938094 | 0.83 | L3MBTL1 (0.50) | ALDH1A1MAPTRAB9AGAANOTUM | |
| SCHEMBL10936334 | 0.81 | ALDH1A1 (0.57) | ALDH1A1MAPTRAB9AGAANPC1 | |
| SCHEMBL10940033 | 0.80 | ALDH1A1 (0.67) | ALDH1A1RAB9AGAASMN1; SMN2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |