Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.37 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10939190 | 0.83 | KMT2A (0.37) | KMT2AMEN1NPSR1HPGDASH1L | |
| SCHEMBL23320081 | 0.81 | KMT2A (0.47) | KMT2AMEN1NPSR1HPGDCNR2 | |
| SCHEMBL10941313 | 0.77 | CNR2 (0.44) | KMT2AMEN1NPSR1HPGDCNR2 | |
| SCHEMBL9811087 | 0.75 | KMT2A (0.41) | KMT2AMEN1NPSR1HPGDPCSK9 | |
| SCHEMBL9273371 | 0.74 | BRD4 (0.46) | KMT2AHPGDPCSK9BRD4GAA | |
| SCHEMBL12441122 | 0.73 | NPSR1 (0.52) | KMT2AMEN1NPSR1HPGDGAA | |
| SCHEMBL6394156 | 0.73 | MAOA (0.42) | KMT2AMEN1NPSR1BRD4CNR2 | |
| SCHEMBL29518719 | 0.71 | KMT2A (0.41) | KMT2AHPGDPCSK9MAPK1BRD4 | |
| SCHEMBL29954969 | 0.70 | MGLL (0.46) | KMT2AMEN1NPSR1HPGDPCSK9 | |
| Silver SCHEMBL4913510 | 0.69 | CNR2 (0.39) | KMT2AMEN1NPSR1BRD4CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |