Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.61 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.56 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.56 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 2/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1093365 | 0.84 | HSD11B1 (0.67) | GLO1SLC40A1SLC22A12PGRHSD11B1 | |
| SCHEMBL1093569 | 0.84 | GLO1 (0.55) | SCN9AGLO1SLC40A1SLC22A12PGR | |
| SCHEMBL1094173 | 0.78 | POLB (0.55) | SCN9A | |
| SCHEMBL1093895 | 0.78 | SLC22A12 (0.69) | SLC22A12 | |
| SCHEMBL1093536 | 0.78 | GLO1 (0.57) | SCN9AGLO1SLC40A1PGRACLY | |
| SCHEMBL15010083 | 0.77 | SCN9A (1.00) | SCN9A | |
| SCHEMBL1095602 | 0.76 | GLO1 (0.53) | SCN9AGLO1SLC40A1SLC22A12PGR | |
| SCHEMBL1093771 | 0.75 | SCN9A (0.56) | SCN9AGLO1SLC40A1SLC22A12PGR | |
| SCHEMBL1094354 | 0.75 | SCN9A (0.52) | SCN9AGLO1SLC40A1SLC22A12PGR | |
| SCHEMBL1094451 | 0.74 | SCN9A (0.62) | SCN9AGLO1SLC40A1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153814-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2012-04-10 | — | — | US | disclosed |