Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLO1 | Q04760 | 1/20 | 0.53 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.53 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.52 |
| ▸ | SCN1A | P35498 | 4/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.50 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | ACLY | P53396 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22634311 | 0.80 | KMT2A (0.54) | SLC40A1SCN9ASCN1ASCN5ASCN8A | |
| SCHEMBL16720161 | 0.80 | SCN1A (0.48) | SCN9ASLC22A12SCN1ASCN5ASCN8A | |
| SCHEMBL1093365 | 0.78 | HSD11B1 (0.67) | GLO1SLC40A1SLC22A12PGRACLY | |
| SCHEMBL1093569 | 0.78 | GLO1 (0.55) | GLO1SLC40A1SCN9ASLC22A12PGR | |
| SCHEMBL1093964 | 0.78 | SCN1A (0.54) | SCN9ASCN1ASCN5ASCN8ANR1I2 | |
| SCHEMBL19617682 | 0.76 | SCN9A (0.46) | SCN9ASLC22A12SCN1ASCN5ASCN8A | |
| SCHEMBL1094074 | 0.76 | SCN9A (0.61) | GLO1SLC40A1SCN9ASLC22A12PGR | |
| SCHEMBL1093895 | 0.75 | SLC22A12 (0.69) | SLC22A12 | |
| SCHEMBL1093536 | 0.75 | GLO1 (0.57) | GLO1SLC40A1SCN9APGRACLY | |
| SCHEMBL1094354 | 0.75 | SCN9A (0.52) | GLO1SLC40A1SCN9ASLC22A12PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8907101-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2014-12-09 | — | — | US | disclosed |
| US-20130338111-A1 | Sulfonamide Derivatives | ICAGEN, INC. (US) | 2013-12-19 | — | — | US | disclosed |
| US-20120149679-A1 | Sulfonamide Derivatives | ICAGEN, INC. | 2012-06-14 | — | — | US | disclosed |
| US-8153814-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2012-04-10 | — | — | US | disclosed |
| US-20100197655-A1 | SULFONAMIDE DERIVATIVES | Pfizer Limited Icagen, Inc. | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197655-A1 | SULFONAMIDE DERIVATIVES | SULT2A1, SULT1A1, TPST2 | GLO1 2222/4885SLC40A1 3958/4885SCN9A 73/4885 |
| US-20130338111-A1 | Sulfonamide Derivatives | SULT2A1, SULT1A1, TPST2 | GLO1 2222/4885SLC40A1 3958/4885SCN9A 73/4885 |
| US-20120149679-A1 | Sulfonamide Derivatives | SULT2A1, SULT1A1, TPST2 | GLO1 2222/4885SLC40A1 3958/4885SCN9A 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.