Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.67 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.62 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | SPR | P35270 | 1/20 | 0.52 |
| ▸ | ACLY | P53396 | 2/20 | 0.52 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1094074 | 0.84 | SCN9A (0.61) | HSD11B1GLO1SLC40A1PGRACLY | |
| SCHEMBL1093569 | 0.83 | GLO1 (0.55) | HSD11B1GLO1SLC40A1ALDH1A1KDM4E | |
| SCHEMBL16897001 | 0.81 | HSD11B1 (0.60) | HSD11B1GLO1SLC40A1KDM4EHTT | |
| SCHEMBL1093895 | 0.80 | SLC22A12 (0.69) | SLC22A12 | |
| SCHEMBL1667129 | 0.78 | KDM4E (0.75) | HSD11B1ALDH1A1KDM4EGAAHTT | |
| SCHEMBL19401395 | 0.78 | MAPT (0.56) | HSD11B1GLO1SLC40A1ALDH1A1KDM4E | |
| SCHEMBL1095602 | 0.78 | GLO1 (0.53) | GLO1SLC40A1PGRACLYSLC22A12 | |
| SCHEMBL19334523 | 0.78 | PGR (0.77) | GLO1SLC40A1ALDH1A1MEN1KMT2A | |
| SCHEMBL16177704 | 0.77 | KDM4E (0.64) | HSD11B1ALDH1A1KDM4EGAAHTT | |
| SCHEMBL1093536 | 0.77 | GLO1 (0.57) | GLO1SLC40A1PGRBRD4ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153814-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2012-04-10 | — | — | US | disclosed |