SCHEMBL10940940

SCHEMBL10940940

CCOC(=O)C1CCCCN1C(=O)Nc1cc(OC(C)C)c(Cl)cc1F

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PPOX P50336 3/20 0.44
KMT2A Q03164 2/20 0.44
MEN1 O00255 1/20 0.44
DHODH Q02127 4/20 0.42
FKBP1A P62942 3/20 0.41
TSHR P16473 3/20 0.40
ALDH1A1 P00352 3/20 0.40
KDM4E B2RXH2 2/20 0.40
GAA P10253 1/20 0.39
MAPK1 P28482 1/20 0.39
RECQL P46063 1/20 0.39
CCR1 P32246 1/20 0.38
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10916762 0.86 KMT2A (0.43) KMT2AMEN1DHODHFKBP1ATSHR
SCHEMBL10919784 0.81 CCR1 (0.43) KMT2AMEN1FKBP1ATSHRALDH1A1
SCHEMBL9769699 0.80 PPOX (0.46) PPOXDHODHTSHRALDH1A1GAA
SCHEMBL11144107 0.79 PPOX (0.40) PPOXDHODHTSHRALDH1A1KDM4E
SCHEMBL10940947 0.77 MEN1 (0.44) PPOXKMT2AMEN1FKBP1ATSHR
SCHEMBL11035154 0.77 KMT2A (0.47) KMT2AMEN1FKBP1ATSHRALDH1A1
SCHEMBL10760257 0.77 MAPT (0.49) PPOXKMT2AFKBP1ATSHRALDH1A1
SCHEMBL10576902 0.76 P2RX3 (0.46) PPOXKMT2AMEN1DHODHTSHR
SCHEMBL10876848 0.76 PPOX (0.41) PPOXKMT2AMEN1DHODHALDH1A1
SCHEMBL10763443 0.75 KMT2A (0.47) PPOXKMT2ADHODHTSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0070389-B1 2-(2-FLUORO-4-HALO-5-SUBSTITUTED PHENYL) HYDANTOINS, AND THEIR PRODUCTION AND USE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1985-10-02 EP disclosed
US-4437877-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-03-20 US disclosed
EP-0070389-A2 2-(2-Fluoro-4-halo-5-substituted phenyl) hydantoins, and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-01-26 EP disclosed