SCHEMBL11035154

SCHEMBL11035154

CCOC(=O)C1CCCCN1C(=O)Nc1cc(C(=O)OC(C)C)c(Cl)cc1Cl

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.47
MEN1 O00255 3/20 0.47
FKBP1A P62942 5/20 0.40
TSHR P16473 4/20 0.40
GAA P10253 2/20 0.40
MAPK1 P28482 1/20 0.39
RECQL P46063 1/20 0.39
ALDH1A1 P00352 3/20 0.38
CCR1 P32246 1/20 0.37
KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10916762 0.92 KMT2A (0.43) KMT2AMEN1FKBP1ATSHRGAA
SCHEMBL10919784 0.80 CCR1 (0.43) KMT2AMEN1FKBP1ATSHRGAA
SCHEMBL10940940 0.77 PPOX (0.44) KMT2AMEN1FKBP1ATSHRGAA
SCHEMBL10916973 0.76 SMN1; SMN2 (0.45) KMT2AMEN1TSHRGAAALDH1A1
SCHEMBL11095505 0.74 TSHR (0.40) KMT2AMEN1TSHRGAAMAPK1
SCHEMBL10990406 0.72 LMNA (0.42) KMT2AMEN1GAAALDH1A1
SCHEMBL27446666 0.70 FKBP1A (0.65) KMT2AMEN1FKBP1AALDH1A1KDM4E
SCHEMBL9781340 0.70 KMT2A (0.44) KMT2AMEN1FKBP1ATSHRGAA
SCHEMBL10647283 0.69 MAPT (0.39) KMT2AMEN1GAAMAPK1ALDH1A1
SCHEMBL10916767 0.69 DHODH (0.37) KMT2AGAACCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-59065070-A None JP disclosed
JP-S5965070-A N-SUBSTITUTED PHENYLCARBAMOYLIMINE DERIVATIVE AND HERBICIDE CONTAINING SAID DERIVATIVE AS ACTIVE COMPONENT NIPPON KAYAKU CO LTD 1984-04-13 JP disclosed