Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683920 | 0.86 | ACE (0.63) | FFAR2HSD17B10ACEPOLBALDH1A1 | |
| SCHEMBL10940664 | 0.78 | ACE (0.75) | FFAR2HSD17B10ACEPOLBALDH1A1 | |
| SCHEMBL10944233 | 0.78 | ACE (0.47) | HSD17B10ACEPOLBALDH1A1KMT2A | |
| SCHEMBL10940821 | 0.77 | GAA (0.46) | FFAR2HSD17B10ACEPOLBALDH1A1 | |
| SCHEMBL10944736 | 0.76 | ACE (0.58) | FFAR2HSD17B10ACEPOLBALDH1A1 | |
| SCHEMBL10945754 | 0.76 | TBXAS1 (0.47) | HSD17B10ACEALDH1A1KDM4E | |
| SCHEMBL10943590 | 0.75 | GAA (0.50) | FFAR2HSD17B10ACEPOLBALDH1A1 | |
| SCHEMBL10943458 | 0.74 | GAA (0.67) | FFAR2HSD17B10ACEPOLBALDH1A1 | |
| SCHEMBL11180379 | 0.74 | FFAR2 (0.52) | FFAR2HSD17B10ACEPOLBALDH1A1 | |
| SCHEMBL11004289 | 0.74 | ACE (0.80) | FFAR2HSD17B10ACEPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031104-B1 | THIAZOLIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-10-23 | — | — | EP | disclosed |
| US-4499102-A | HYPOTENSIVE AND ANTIDIABETIC AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-02-12 | — | — | US | disclosed |
| EP-0031104-A1 | Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1981-07-01 | — | — | EP | disclosed |