Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 11/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9853999 | 0.80 | POLB (0.58) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL10943470 | 0.80 | ACE (0.43) | ACEHSD17B10 | |
| SCHEMBL10942483 | 0.80 | ACE (0.43) | ACEHSD17B10 | |
| SCHEMBL10946334 | 0.80 | ACE (0.49) | KDM4EACEHSD17B10 | |
| SCHEMBL10945275 | 0.80 | FFAR2 (0.48) | ALDH1A1ACEHSD17B10 | |
| SCHEMBL10940821 | 0.80 | GAA (0.46) | ALDH1A1ACEHSD17B10 | |
| Acetic Acid SCHEMBL9854087 | 0.79 | POLB (0.57) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL10944246 | 0.79 | L3MBTL1 (0.44) | ALDH1A1ACE | |
| SCHEMBL10942993 | 0.79 | L3MBTL1 (0.44) | ALDH1A1ACE | |
| SCHEMBL10939993 | 0.79 | ACE (0.57) | ALDH1A1ACEHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031104-B1 | THIAZOLIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-10-23 | — | — | EP | disclosed |
| US-4499102-A | HYPOTENSIVE AND ANTIDIABETIC AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-02-12 | — | — | US | disclosed |
| EP-0031104-A1 | Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1981-07-01 | — | — | EP | disclosed |