Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | SHBG | P04278 | 1/20 | 0.33 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL10941848 | 0.91 | TDP1 (0.51) | TDP1LMNAPGRNR3C1PDE4D | |
| SCHEMBL6707126 | 0.83 | LMNA (0.50) | TDP1LMNAPGRNR3C1PDE4D | |
| SCHEMBL10885823 | 0.83 | CYP19A1 (0.35) | TDP1LMNAPGRNR3C1PDE4D | |
| SCHEMBL6707070 | 0.79 | PGR (0.57) | TDP1LMNAPGRNR3C1PDE4D | |
| SCHEMBL6707066 | 0.79 | PGR (0.57) | TDP1LMNAPGRNR3C1PDE4D | |
| SCHEMBL10883611 | 0.77 | SHBG (0.46) | LMNAPGRNR3C1MEN1KMT2A | |
| SCHEMBL10946076 | 0.77 | SHBG (0.46) | LMNAPGRNR3C1MEN1KMT2A | |
| SCHEMBL10883431 | 0.75 | PGR (0.42) | TDP1LMNAPGRNR3C1PDE4D | |
| SCHEMBL10886110 | 0.74 | TDP1 (0.40) | TDP1LMNAPGRNR3C1PDE4D | |
| SCHEMBL10886114 | 0.74 | TDP1 (0.40) | TDP1LMNAPGRNR3C1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4502989-A | HYPOTENSIVE, ANTIEDEMIC | SHIONOGI & CO., LTD. (JP) | 1985-03-05 | — | — | US | claimed |
| EP-0115273-A2 | Aldosterone-antagonistic steroids | SHIONOGI & CO., LTD. (JP) | 1984-08-08 | — | — | EP | claimed |
| US-4502989-A | HYPOTENSIVE, ANTIEDEMIC | SHIONOGI & CO., LTD. (JP) | 1985-03-05 | — | — | US | disclosed |
| EP-0115273-A2 | Aldosterone-antagonistic steroids | SHIONOGI & CO., LTD. (JP) | 1984-08-08 | — | — | EP | disclosed |