Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | PGR | P06401 | 2/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SHBG | P04278 | 1/20 | 0.33 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10945226 | 0.91 | TDP1 (0.40) | TDP1LMNAPGRNR3C1PDE4D | |
| SCHEMBL10885662 | 0.80 | TDP1 (0.38) | TDP1LMNAPGRNR3C1PDE4D | |
| Potassium Ion SCHEMBL10883779 | 0.79 | PGR (0.70) | TDP1LMNAPGRNR3C1PDE4D | |
| Potassium Ion SCHEMBL10883783 | 0.79 | PGR (0.70) | TDP1LMNAPGRNR3C1PDE4D | |
| Potassium Ion SCHEMBL10945748 | 0.79 | PGR (0.70) | TDP1LMNAPGRNR3C1PDE4D | |
| Potassium Ion SCHEMBL10882834 | 0.78 | LMNA (0.54) | TDP1LMNAPGRNR3C1PDE4D | |
| Potassium Ion SCHEMBL10882830 | 0.78 | LMNA (0.54) | TDP1LMNAPGRNR3C1PDE4D | |
| Potassium Ion SCHEMBL10943822 | 0.78 | LMNA (0.54) | TDP1LMNAPGRNR3C1PDE4D | |
| Potassium Ion SCHEMBL10885466 | 0.76 | TDP1 (0.51) | TDP1LMNAPGRNR3C1PDE4D | |
| Potassium Ion SCHEMBL10885472 | 0.76 | TDP1 (0.51) | TDP1LMNAPGRNR3C1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4502989-A | HYPOTENSIVE, ANTIEDEMIC | SHIONOGI & CO., LTD. (JP) | 1985-03-05 | — | — | US | claimed |
| EP-0115273-A2 | Aldosterone-antagonistic steroids | SHIONOGI & CO., LTD. (JP) | 1984-08-08 | — | — | EP | claimed |
| US-4502989-A | HYPOTENSIVE, ANTIEDEMIC | SHIONOGI & CO., LTD. (JP) | 1985-03-05 | — | — | US | disclosed |
| EP-0115273-A2 | Aldosterone-antagonistic steroids | SHIONOGI & CO., LTD. (JP) | 1984-08-08 | — | — | EP | disclosed |