Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefotiam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 13/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.87 |
| ▸ | LMNA | P02545 | 4/20 | 0.87 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.86 |
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | POLB | P06746 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | APEX1 | P27695 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefotiam SCHEMBL10948356 | 1.00 | TDP1 (0.87) | TDP1HSD17B10LMNAL3MBTL1MAPT | |
| Cefotiam SCHEMBL9693095 | 0.99 | TDP1 (0.87) | TDP1HSD17B10LMNAL3MBTL1MAPT | |
| Cefotiam SCHEMBL9693154 | 0.99 | TDP1 (0.87) | TDP1HSD17B10LMNAL3MBTL1MAPT | |
| Cefotiam SCHEMBL9754126 | 0.93 | TDP1 (1.00) | TDP1HSD17B10LMNAL3MBTL1MAPT | |
| Cefotiam SCHEMBL149538 | 0.93 | TDP1 (1.00) | TDP1HSD17B10LMNAL3MBTL1MAPT | |
| Cefotiam SCHEMBL9754124 | 0.93 | TDP1 (1.00) | TDP1HSD17B10LMNAL3MBTL1MAPT | |
| Cefotiam SCHEMBL16473046 | 0.93 | TDP1 (1.00) | TDP1HSD17B10LMNAL3MBTL1MAPT | |
| Cefotiam SCHEMBL11095123 | 0.93 | TDP1 (1.00) | TDP1HSD17B10LMNAL3MBTL1MAPT | |
| Cefotiam SCHEMBL6019446 | 0.93 | TDP1 (1.00) | TDP1HSD17B10LMNAL3MBTL1MAPT | |
| Cefotiam SCHEMBL65480 | 0.93 | L3MBTL1 (1.00) | TDP1HSD17B10LMNAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4497809-A | ANTIBIOTICS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1985-02-05 | — | — | US | disclosed |
| EP-0093548-A2 | Cephalosporin derivatives | Takeda Chemical Industries, Ltd. (JP) | 1983-11-09 | — | — | EP | disclosed |