Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefotiam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 13/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.87 |
| ▸ | LMNA | P02545 | 4/20 | 0.87 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.86 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | POLB | P06746 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | APEX1 | P27695 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefotiam SCHEMBL9693095 | 1.00 | TDP1 (0.87) | TDP1HSD17B10LMNAL3MBTL1NR1I2 | |
| Cefotiam SCHEMBL10948375 | 0.99 | TDP1 (0.87) | TDP1HSD17B10LMNAL3MBTL1NR1I2 | |
| Cefotiam SCHEMBL10948356 | 0.99 | TDP1 (0.87) | TDP1HSD17B10LMNAL3MBTL1NR1I2 | |
| Cefotiam SCHEMBL9754126 | 0.93 | TDP1 (1.00) | TDP1HSD17B10LMNAL3MBTL1NR1I2 | |
| Cefotiam SCHEMBL6019446 | 0.93 | TDP1 (1.00) | TDP1HSD17B10LMNAL3MBTL1NR1I2 | |
| Cefotiam SCHEMBL9754124 | 0.93 | TDP1 (1.00) | TDP1HSD17B10LMNAL3MBTL1NR1I2 | |
| Cefotiam SCHEMBL16473046 | 0.93 | TDP1 (1.00) | TDP1HSD17B10LMNAL3MBTL1NR1I2 | |
| Cefotiam SCHEMBL11095123 | 0.93 | TDP1 (1.00) | TDP1HSD17B10LMNAL3MBTL1NR1I2 | |
| Cefotiam SCHEMBL149538 | 0.93 | TDP1 (1.00) | TDP1HSD17B10LMNAL3MBTL1NR1I2 | |
| Cefotiam SCHEMBL65480 | 0.93 | L3MBTL1 (1.00) | TDP1HSD17B10LMNAL3MBTL1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120841-A | Antibiotics for easy absorption | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-06-09 | — | — | US | disclosed |
| EP-0128029-B1 | CEPHALOSPORIN ESTER DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1989-02-08 | — | — | EP | disclosed |
| US-4797395-A | ANTIBIOTICS, BACTERICIDES, AMINOALKYLTETRAZOLETHIO | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-01-10 | — | — | US | disclosed |
| US-4755598-A | 1'-(substituted)ethyl-7β-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl]thio]methyl]ceph-3-em-4-carboxylate derivatives having antibacterial utility | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-07-05 | — | — | US | disclosed |
| US-4725592-A | 1-Acyloxyalkyl esters of cephalosporin | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| US-4616008-A | LIPID-SOLUBLE CEPHALOSPORINS AND CYCLODEXTRINS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-10-07 | — | — | US | disclosed |
| US-4593115-A | REACTING ALDEHYDE WITH ACYL CHLORIDE AND SODIUM IODIDE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-06-03 | — | — | US | disclosed |
| EP-0128029-A2 | Cephalosporin ester derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1984-12-12 | — | — | EP | disclosed |
| US-4316018-A | PIVALOYLOXYMETHYL 7B-(2-(2-AMINOTHIAZOL-4-YL)ACETAMIDO)-3-(((1-(2-DIMETHYL AMINOETHYL)-1H-TETRAZOL-5-YL)THIO)METHYL)CEPH-3-EM-4-CARBOXYLATE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-02-16 | — | — | US | disclosed |
| US-4189479-A | Cephalosporin esters | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-02-19 | — | — | US | disclosed |