Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27490739 | 0.82 | DPP7 (0.42) | MAPTL3MBTL1MAPK1NPSR1ALDH1A1 | |
| SCHEMBL8303530 | 0.75 | MAPT (0.54) | MAPTL3MBTL1MAPK1NPSR1ALDH1A1 | |
| SCHEMBL8507598 | 0.73 | MAPT (0.51) | MAPTL3MBTL1MAPK1NPSR1ALDH1A1 | |
| Pyrrole SCHEMBL28332410 | 0.73 | GAA (0.36) | MAPK1ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL3307848 | 0.73 | MAPT (0.40) | MAPTL3MBTL1MAPK1NPSR1ALDH1A1 | |
| SCHEMBL4447945 | 0.72 | MAPT (0.40) | MAPTL3MBTL1MAPK1NPSR1ALDH1A1 | |
| SCHEMBL3307231 | 0.71 | MAPT (0.37) | MAPTL3MBTL1MAPK1NPSR1ALDH1A1 | |
| SCHEMBL22500187 | 0.70 | SIGMAR1 (0.48) | MAPTL3MBTL1MAPK1NPSR1ALDH1A1 | |
| SCHEMBL20594028 | 0.69 | L3MBTL1 (0.54) | MAPTL3MBTL1MAPK1NPSR1ALDH1A1 | |
| SCHEMBL8303682 | 0.69 | L3MBTL1 (0.54) | MAPTL3MBTL1MAPK1NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0046289-B1 | SUBSTITUTED ENANTHOLACTAM DERIVATIVES AS ANTIHYPERTENSIVES, A PROCESS FOR PREPARING AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND INTERMEDIATES | MERCK & CO. INC. (US) | 1985-11-27 | — | — | EP | disclosed |