Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2403850 | 0.90 | MEN1 (0.62) | TSHRRAB9AGAANPC1MEN1 | |
| SCHEMBL2406730 | 0.84 | KMT2A (0.65) | TSHRRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5598097 | 0.81 | MEN1 (0.54) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10952765 | 0.81 | NPSR1 (0.53) | RAB9AGAASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL9671985 | 0.81 | TSHR (0.77) | TSHRRAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL2840870 | 0.79 | TSHR (0.74) | TSHRRAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL2840873 | 0.79 | TSHR (0.74) | TSHRRAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL12319372 | 0.79 | POLB (0.42) | TSHRGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL13966687 | 0.79 | NPC1 (0.53) | RAB9AGAASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5879030 | 0.79 | RAB9A (0.88) | TSHRRAB9AGAASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4536346-A | TREATMENT OF ATHEROSCLEROSIS | AMERICAN CYANAMID COMPANY (US) | 1985-08-20 | — | — | US | disclosed |
| US-4489090-A | ATHEROSCLEROSIS | AMERICAN CYANAMID COMPANY (US) | 1984-12-18 | — | — | US | disclosed |
| EP-0124791-A1 | Aralkanamidophenyl compounds | AMERICAN CYANAMID COMPANY (US) | 1984-11-14 | — | — | EP | disclosed |