Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13966687 | 0.91 | NPC1 (0.53) | MAPTGAAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3447255 | 0.84 | LMNA (0.50) | GAASMN1; SMN2HTTRAB9A | |
| SCHEMBL5598097 | 0.84 | MEN1 (0.54) | MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12497355 | 0.83 | KDM4E (0.47) | NPSR1MAPTGAAALDH1A1HPGD | |
| SCHEMBL12319372 | 0.82 | POLB (0.42) | MAPTGAAALDH1A1SMN1; SMN2EPHX2 | |
| SCHEMBL2403850 | 0.82 | MEN1 (0.62) | MAPTGAAALDH1A1HPGDMAPK1 | |
| SCHEMBL3091545 | 0.82 | NPSR1 (0.47) | NPSR1MAPTGAANOTUMALDH1A1 | |
| SCHEMBL10951354 | 0.81 | TSHR (0.63) | MAPTGAAALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL13653517 | 0.80 | GAA (0.51) | MAPTGAAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4817806 | 0.80 | HPGD (0.53) | MAPTALDH1A1HPGDSMN1; SMN2ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4536346-A | TREATMENT OF ATHEROSCLEROSIS | AMERICAN CYANAMID COMPANY (US) | 1985-08-20 | — | — | US | disclosed |
| EP-0124791-A1 | Aralkanamidophenyl compounds | AMERICAN CYANAMID COMPANY (US) | 1984-11-14 | — | — | EP | disclosed |