Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10951354 | 0.90 | TSHR (0.63) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL5598097 | 0.82 | MEN1 (0.54) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL10952765 | 0.82 | NPSR1 (0.53) | RAB9ANPC1MAPTALDH1A1HPGD | |
| SCHEMBL13966687 | 0.80 | NPC1 (0.53) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL12319372 | 0.80 | POLB (0.42) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL3447255 | 0.79 | LMNA (0.50) | MEN1KMT2ALMNARAB9AGAA | |
| SCHEMBL8401925 | 0.78 | KMT2A (0.79) | MEN1KMT2ALMNARAB9ANPC1 | |
| SCHEMBL8661871 | 0.76 | MEN1 (0.82) | MEN1KMT2ALMNARAB9ANPC1 | |
| SCHEMBL73418 | 0.76 | LOXL2 (0.53) | MEN1KMT2ALMNARAB9ANPC1 | |
| SCHEMBL11055062 | 0.75 | MAPT (0.53) | MEN1KMT2ALMNARAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722730-B2 | 5-membered heterocyclic compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2014-05-13 | — | — | US | disclosed |
| US-8722730-B2 | 5-membered heterocyclic compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2014-05-13 | — | — | US | disclosed |
| US-20110213156-A1 | 5-MEMBERED HETEROCYCLIC COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-09-01 | — | — | US | disclosed |
| US-20110213156-A1 | 5-MEMBERED HETEROCYCLIC COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-09-01 | — | — | US | disclosed |
| EP-2189445-A1 | FIVE-MEMBERED HETEROCYCLIC COMPOUND | Research Foundation Itsuu Laboratory (JP) | 2010-05-26 | — | — | EP | disclosed |
| EP-2189445-A1 | FIVE-MEMBERED HETEROCYCLIC COMPOUND | Research Foundation Itsuu Laboratory (JP) | 2010-05-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110213156-A1 | 5-MEMBERED HETEROCYCLIC COMPOUND | RXRA, RXRG, RXRB | MEN1 1614/4885KMT2A 2788/4885LMNA 783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.