Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.52 |
| ▸ | RGS12 | O14924 | 1/20 | 0.52 |
| ▸ | PMM2 | O15305 | 1/20 | 0.52 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916776 | 0.72 | LMNA (0.48) | LMNAMAPTNPSR1ALDH1A1HPGD | |
| Ebselen SCHEMBL29370082 | 0.71 | METAP2 (1.00) | LMNAMAPTNPSR1ALDH1A1HPGD | |
| Ebselen SCHEMBL4406056 | 0.71 | METAP2 (1.00) | LMNAMAPTNPSR1ALDH1A1HPGD | |
| Ebselen SCHEMBL33829 | 0.71 | METAP2 (1.00) | LMNAMAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL5916587 | 0.70 | METAP2 (0.62) | LMNAMAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL28630176 | 0.70 | METAP2 (0.54) | LMNAMAPTNPSR1ALDH1A1HPGD | |
| Ebselen SCHEMBL19064566 | 0.70 | METAP2 (0.96) | LMNAMAPTNPSR1ALDH1A1HPGD | |
| Ebselen SCHEMBL20678555 | 0.70 | METAP2 (0.96) | LMNAMAPTNPSR1ALDH1A1HPGD | |
| Ebselen SCHEMBL20477111 | 0.70 | METAP2 (0.96) | LMNAMAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL21568696 | 0.69 | MAPT (1.00) | LMNAMAPTNPC1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4550168-A | Benzisoselenazolones and a process for the treatment of inflammatory diseases | A. NATTERMANN & CIE GMBH (DE) | 1985-10-29 | — | — | US | disclosed |
| EP-0100899-A2 | Benzisoselenazolones, process for their preparation and pharmaceutical compositions containing them | A. Nattermann & Cie. GmbH (DE) | 1984-02-22 | — | — | EP | disclosed |