Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421953 | 0.90 | ALDH1A1 (0.35) | ALDH1A1CYP3A4HPGDPPARD | |
| SCHEMBL23748174 | 0.80 | ALDH1A1 (0.39) | ALDH1A1CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL10153555 | 0.78 | CYP3A4 (0.38) | ALDH1A1CYP3A4L3MBTL1HPGD | |
| SCHEMBL10153576 | 0.76 | NOTUM (0.47) | CYP3A4HPGDCXCL12 | |
| SCHEMBL30951357 | 0.72 | HPGD (0.43) | ALDH1A1CYP3A4MEN1CYP2C19KMT2A | |
| SCHEMBL1105439 | 0.72 | HPGD (0.43) | ALDH1A1CYP3A4MEN1CYP2C19KMT2A | |
| SCHEMBL14817465 | 0.68 | NOTUM (0.51) | ALDH1A1MEN1CYP1A2CYP2C19KMT2A | |
| SCHEMBL421721 | 0.67 | CA12 (0.52) | ALDH1A1CYP2C19HPGD | |
| SCHEMBL423901 | 0.65 | GPR35 (0.41) | ALDH1A1CYP3A4CYP1A2CYP2C19HPGD | |
| SCHEMBL8893819 | 0.65 | NPC1 (0.41) | CYP3A4CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585456-B1 | AMIDO-TROPANE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2015-09-16 | — | — | EP | disclosed |
| EP-2585456-A1 | AMIDO-TROPANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-01 | — | — | EP | disclosed |
| US-8153653-B2 | Amido-tropane derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153653-B2 | Amido-tropane derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-04-10 | — | — | US | disclosed |
| WO-2011161006-A1 | AMIDO-TROPANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-29 | — | — | WO | disclosed |
| WO-2011161006-A1 | AMIDO-TROPANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-29 | — | — | WO | disclosed |
| US-20110312993-A1 | AMIDO-TROPANE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2011-12-22 | — | — | US | disclosed |
| US-20110312993-A1 | AMIDO-TROPANE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312993-A1 | AMIDO-TROPANE DERIVATIVES | SLC1A2, SLC18A2, SLC6A1 | ALDH1A1 1491/4885CYP3A4 1229/4885MEN1 2953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.