Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10957087 | 0.87 | ALDH1A1 (0.33) | ALDH1A1NPC1RAB9ACLK2GSK3A | |
| SCHEMBL11436299 | 0.70 | HPGD (0.36) | LMNACYP1A2CYP3A4MAPTALDH1A1 | |
| SCHEMBL10954889 | 0.70 | KDM4E (0.38) | LMNAMAPTALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL11496465 | 0.69 | LMNA (0.34) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL10958239 | 0.68 | MAPT (0.34) | LMNAMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL5940563 | 0.64 | LMNA (0.64) | LMNATSHRCYP2C19MAPTALDH1A1 | |
| SCHEMBL10955467 | 0.63 | CLK2 (0.65) | MAPTALDH1A1NPC1RAB9ACLK2 | |
| SCHEMBL10580743 | 0.61 | RARB (0.57) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL3792565 | 0.60 | HSD17B3 (0.70) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL6653668 | 0.60 | RARB (0.58) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008047-B1 | 5(6)-(2-AMINO-5-THIAZOLOYL)BENZIMIDAZOLE-2-CARBAMIC ACID ESTERS AND THEIR SALTS, THEIR PREPARATION AND USE, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1985-12-04 | — | — | EP | disclosed |