Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10956171 | 1.00 | LMNA (0.45) | LMNACES2CES1POLBTSHR | |
| SCHEMBL12714065 | 0.78 | CES2 (0.50) | LMNACES2CES1TSHRL3MBTL1 | |
| SCHEMBL11124456 | 0.78 | METTL3 (0.42) | CES2CES1ATMALDH1A1MAPT | |
| SCHEMBL11124453 | 0.78 | METTL3 (0.42) | CES2CES1ATMALDH1A1MAPT | |
| SCHEMBL1838629 | 0.78 | TSHR (0.44) | TSHRMAPTEGFRPHGDHSMN1; SMN2 | |
| SCHEMBL1838631 | 0.78 | TSHR (0.44) | TSHRMAPTEGFRPHGDHSMN1; SMN2 | |
| SCHEMBL12285402 | 0.77 | MAPT (0.42) | POLBTSHRL3MBTL1CYP3A4ATM | |
| SCHEMBL1839901 | 0.77 | MAPT (0.42) | POLBTSHRL3MBTL1CYP3A4ATM | |
| SCHEMBL1839902 | 0.77 | MAPT (0.42) | POLBTSHRL3MBTL1CYP3A4ATM | |
| SCHEMBL6662812 | 0.77 | ALOX15 (0.52) | LMNACES2CES1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0135252-A2 | Process for preparing 3-substituted-3-aminonitrile | ELI LILLY AND COMPANY (US) | 1985-03-27 | — | — | EP | disclosed |
| EP-0129407-A2 | Improvements in and relating to (3-aryl-5-isothiazolyl)ureas | ELI LILLY AND COMPANY (US) | 1984-12-27 | — | — | EP | disclosed |