Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALPL | P05186 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10710253 | 0.81 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2KMT2AALPLCA1 | |
| SCHEMBL14520037 | 0.79 | KMT2A (0.57) | ALDH1A1SMN1; SMN2KMT2AMEN1L3MBTL1 | |
| SCHEMBL2446081 | 0.79 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KMT2AALPLCA1 | |
| SCHEMBL4944543 | 0.79 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2KMT2AALPLCA1 | |
| SCHEMBL2446085 | 0.79 | CA2 (0.57) | ALDH1A1SMN1; SMN2KMT2AALPLCA1 | |
| SCHEMBL11148251 | 0.79 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KMT2AALPLCA1 | |
| SCHEMBL29469839 | 0.79 | CA2 (0.57) | ALDH1A1SMN1; SMN2KMT2AALPLCA1 | |
| SCHEMBL14519874 | 0.79 | L3MBTL1 (0.60) | ALDH1A1SMN1; SMN2KMT2ANPSR1L3MBTL1 | |
| SCHEMBL10957051 | 0.78 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2KMT2AALPLCA1 | |
| SCHEMBL14519921 | 0.78 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2KMT2AALPLWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0088346-B1 | 2-AMINOMETHYL-PHENOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-06-05 | — | — | EP | disclosed |
| EP-0088346-A2 | 2-Aminomethyl-phenol derivatives, process for their preparation, their use and pharmaceutical compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-09-14 | — | — | EP | disclosed |