Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10963776 | 0.85 | PDE5A (0.39) | PDE5AALDH1A1CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL10962015 | 0.84 | ESR1 (0.36) | EGFRCYP3A4AMY1APOLBCYP17A1 | |
| SCHEMBL10960696 | 0.81 | METAP2 (0.49) | PDE5ARAB9AALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL11233385 | 0.79 | AMY1A (0.41) | EGFRPDE5AALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL10962037 | 0.79 | PDE5A (0.50) | PDE5ARAB9AALDH1A1HSD17B10AMY1A | |
| Hydrochloric Acid SCHEMBL10961558 | 0.78 | PDE5A (0.51) | PDE5ARAB9AALDH1A1HSD17B10AMY1A | |
| SCHEMBL10869538 | 0.78 | SLC2A1 (0.44) | EGFRPDE5ARAB9AALDH1A1CYP1A2 | |
| SCHEMBL10983982 | 0.76 | CYP17A1 (0.33) | EGFRAMY1ACYP17A1CYP11B1CYP11B2 | |
| SCHEMBL10965860 | 0.76 | EGFR (0.32) | EGFRAMY1A | |
| SCHEMBL10980453 | 0.74 | PDE5A (0.35) | PDE5AGUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0142235-A1 | Naphthalenylimidazopyridine and derivatives and their preparation | ELI LILLY AND COMPANY (US) | 1985-05-22 | — | — | EP | disclosed |
| US-4515796-A | INOTROPIC, BRONCHODILATOR, VASODILATORS, ANTICOAGULANTS | ELI LILLY AND COMPANY (US) | 1985-05-07 | — | — | US | disclosed |