Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.41 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11352539 | 0.88 | AMY1A (0.31) | AMY1A | |
| SCHEMBL10691368 | 0.82 | AMY1A (0.41) | AMY1AALDH1A1CYP3A4 | |
| SCHEMBL10960693 | 0.79 | EGFR (0.36) | AMY1APDE5AEGFRALDH1A1CYP3A4 | |
| SCHEMBL7279881 | 0.79 | AMY1A (0.47) | AMY1APDE5AALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7277923 | 0.78 | AMY1A (0.46) | AMY1APDE5AALDH1A1SMN1; SMN2 | |
| SCHEMBL10963776 | 0.76 | PDE5A (0.39) | AMY1APDE5AALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL10962015 | 0.75 | ESR1 (0.36) | AMY1AEGFRCYP3A4 | |
| SCHEMBL10965568 | 0.75 | METAP2 (0.41) | AMY1APDE5AALDH1A1HSD17B10 | |
| SCHEMBL10678378 | 0.75 | AMY1A (0.49) | AMY1APDE5AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL10961186 | 0.75 | TNKS (0.33) | AMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024290-B1 | 8-PHENYL PURINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1982-12-22 | — | — | EP | claimed |
| US-4299834-A | INOTROPIC ACTIVITY | BOEHRINGER INGELHEIM GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-11-10 | — | — | US | claimed |
| EP-0024290-A1 | 8-Phenyl purines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-03-04 | — | — | EP | claimed |
| EP-0024290-B1 | 8-PHENYL PURINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1982-12-22 | — | — | EP | disclosed |
| US-4299834-A | INOTROPIC ACTIVITY | BOEHRINGER INGELHEIM GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-11-10 | — | — | US | disclosed |
| EP-0024290-A1 | 8-Phenyl purines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-03-04 | — | — | EP | disclosed |