Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | CDK4 | P11802 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | CCND3 | P30281 | 2/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10960693 | 0.84 | EGFR (0.36) | AMY1ACYP17A1CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL11006162 | 0.82 | CDK4 (0.43) | ESR1ESR2CDK4CDK2CCNA2 | |
| SCHEMBL10962019 | 0.82 | GUSB (0.40) | ESR1ESR2CDK4CDK2CCNA2 | |
| SCHEMBL10965537 | 0.80 | EGFR (0.44) | AMY1ACYP17A1CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL10963776 | 0.79 | PDE5A (0.39) | AMY1ACDK1CYP3A4 | |
| SCHEMBL10965860 | 0.78 | EGFR (0.32) | AMY1AEGFR | |
| SCHEMBL11233385 | 0.75 | AMY1A (0.41) | AMY1ACYP3A4EGFR | |
| SCHEMBL10960260 | 0.73 | ALDH1A1 (0.35) | EGFRLMNA | |
| SCHEMBL10983982 | 0.72 | CYP17A1 (0.33) | AMY1ACYP17A1CYP11B1CYP11B2EGFR | |
| SCHEMBL10959064 | 0.72 | MAPT (0.30) | KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0142235-A1 | Naphthalenylimidazopyridine and derivatives and their preparation | ELI LILLY AND COMPANY (US) | 1985-05-22 | — | — | EP | disclosed |
| US-4515796-A | INOTROPIC, BRONCHODILATOR, VASODILATORS, ANTICOAGULANTS | ELI LILLY AND COMPANY (US) | 1985-05-07 | — | — | US | disclosed |