Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SORD | Q00796 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9418612 | 0.82 | SORD (0.49) | ALDH1A1MAPTL3MBTL1MAPK1SORD | |
| SCHEMBL11211440 | 0.77 | HSD17B10 (0.43) | ALDH1A1MAPTL3MBTL1MAPK1KDM4E | |
| SCHEMBL9336873 | 0.73 | HRH1 (0.50) | ALDH1A1L3MBTL1MAPK1SORDRAB9A | |
| SCHEMBL11162860 | 0.73 | KDM4E (0.51) | ALDH1A1MAPTL3MBTL1MAPK1KDM4E | |
| SCHEMBL27722984 | 0.73 | KMT2A (0.51) | ALDH1A1MAPTL3MBTL1MAPK1KDM4E | |
| SCHEMBL12903094 | 0.72 | KMT2A (0.55) | KMT2A | |
| SCHEMBL27451339 | 0.72 | SORD (0.40) | ALDH1A1MAPTL3MBTL1MAPK1SORD | |
| SCHEMBL3057499 | 0.72 | HTT (0.55) | ALDH1A1MAPTL3MBTL1MAPK1KDM4E | |
| SCHEMBL2242665 | 0.72 | SMN1; SMN2 (0.52) | ALDH1A1L3MBTL1MAPK1SORDRAB9A | |
| SCHEMBL778332 | 0.72 | SMN1; SMN2 (0.52) | ALDH1A1L3MBTL1MAPK1SORDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055583-B1 | ANTIHYPERTENSIVES | Pfizer Limited (GB) | 1985-08-28 | — | — | EP | disclosed |
| US-4483859-A | 4-Amino-6, 7-dimethoxy-2-(4-heteroaryl-piperazino) quinazoline _antihypertensives | PFIZER INC. (US) | 1984-11-20 | — | — | US | disclosed |
| US-4483857-A | 4-Amino-6,7-dimethoxy-2-(4-heteroaryl-piperazino)quinazoline antihypertensives | PFIZER INC. (US) | 1984-11-20 | — | — | US | disclosed |
| US-4435401-A | 4-Amino-6,7-dimethoxy-2-(4-heteroaryl-piperazino)quinazoline antihypertensives | PFIZER INC. (US) | 1984-03-06 | — | — | US | disclosed |
| EP-0055583-A1 | Antihypertensives | Pfizer Limited (GB) | 1982-07-07 | — | — | EP | disclosed |