Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11162860 | 0.84 | KDM4E (0.51) | HSD17B10ALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL10965406 | 0.77 | ALDH1A1 (0.40) | HSD17B10ALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL8717879 | 0.77 | AKR1C3 (0.54) | ALDH1A1L3MBTL1MAPTKDM4EMEN1 | |
| SCHEMBL11394247 | 0.75 | CETP (0.62) | ALDH1A1MAPTKDM4ECETPGAA | |
| SCHEMBL11215614 | 0.74 | HTR3E (0.58) | KDM4ECETPKMT2ATDP1NPSR1 | |
| Hydrochloric Acid SCHEMBL11217986 | 0.72 | HTR3A (0.56) | ALDH1A1KDM4ECETPKMT2ATDP1 | |
| SCHEMBL9070630 | 0.70 | TDP1 (0.55) | ALDH1A1MAPK1L3MBTL1MAPTKDM4E | |
| SCHEMBL6371066 | 0.68 | HTR3A (0.68) | ALDH1A1KDM4EHRH4HRH3RAB9A | |
| SCHEMBL11396110 | 0.68 | KDM4E (0.61) | ALDH1A1MAPK1MAPTKDM4EHTR6 | |
| SCHEMBL11394205 | 0.68 | GAA (0.58) | ALDH1A1MAPTHTR6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351832-A | 2-(Piperazinyl)-4-pyrimidinamines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-28 | — | — | US | disclosed |
| US-4333937-A | 2-(Piperazinyl)-4-pyrimioinamines | AMERICAN HOME PRODUCTS CORP. (US) | 1982-06-08 | — | — | US | disclosed |
| EP-0039190-A1 | 2-(1-Piperazinyl)-4-pyrimidinamines and related compounds | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-11-04 | — | — | EP | disclosed |
| WO-1981003022-A1 | 2-(1-PIPERAZINYL)-4-PYRIMIDINAMINES | AMERICAN HOME PROD (US) | 1981-10-29 | — | — | WO | disclosed |
| EP-0056027-A1 | 2-(1-PIPERAZINYL)-4-PYRIMIDINAMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-10-29 | — | — | EP | disclosed |