Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pirenperone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 4/20 | 0.48 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.48 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.48 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.48 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.48 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 6/20 | 0.93 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.93 |
| ▸ | MAPT | P10636 | 3/20 | 0.93 |
| ▸ | TSHR | P16473 | 3/20 | 0.93 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.93 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.93 |
| ▸ | HTR1A | P08908 | 3/20 | 0.93 |
| ▸ | MEN1 | O00255 | 2/20 | 0.93 |
| ▸ | PKM | P14618 | 2/20 | 0.93 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.93 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.93 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.93 |
| ▸ | HPGD | P15428 | 1/20 | 0.93 |
| ▸ | THPO | P40225 | 1/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pirenperone SCHEMBL467209 | 0.96 | HTR2C (1.00) | HTR2CCYP2D6MAPTTSHRKDM4E | |
| Pirenperone SCHEMBL10965711 | 0.96 | HTR2C (0.98) | HTR2CCYP2D6MAPTTSHRKDM4E | |
| Pirenperone SCHEMBL10970070 | 0.93 | HTR2C (0.93) | HTR2CCYP2D6MAPTTSHRKDM4E | |
| Pirenperone SCHEMBL11242425 | 0.91 | CYP2D6 (0.89) | HTR2CCYP2D6MAPTTSHRKDM4E | |
| SCHEMBL17532707 | 0.89 | CYP2D6 (0.86) | HTR2CCYP2D6MAPTTSHRKDM4E | |
| SCHEMBL10967011 | 0.89 | CYP2D6 (0.86) | HTR2CCYP2D6MAPTTSHRKDM4E | |
| SCHEMBL6527939 | 0.84 | HTR2C (0.77) | HTR2CCYP2D6MAPTTSHRKDM4E | |
| Metrenperone SCHEMBL2109868 | 0.84 | HTR2C (0.77) | HTR2CCYP2D6MAPTTSHRKDM4E | |
| SCHEMBL6522324 | 0.83 | HTR2C (0.76) | HTR2CCYP2D6MAPTTSHRKDM4E | |
| SCHEMBL10963572 | 0.83 | CYP2D6 (0.75) | HTR2CCYP2D6MAPTTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0037265-B1 | 3-(1-PIPERIDINYLALKYL)-4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-01-23 | — | — | EP | disclosed |
| US-4342870-A | SEROTONIN ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-08-03 | — | — | US | disclosed |
| EP-0037265-A1 | 3-(1-piperidinylalkyl)-4H-pyrido(1,2-a)pyrimidin-4-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-10-07 | — | — | EP | disclosed |