Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pirenperone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 0.48 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.46 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.46 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.46 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.46 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.46 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.46 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.89 |
| ▸ | HTR2C | P28335 | 5/20 | 0.89 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.89 |
| ▸ | TSHR | P16473 | 4/20 | 0.89 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.89 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.89 |
| ▸ | MAPT | P10636 | 3/20 | 0.89 |
| ▸ | HTR1A | P08908 | 3/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pirenperone SCHEMBL467209 | 0.94 | HTR2C (1.00) | CYP2D6HTR2CKDM4ETSHRCYP3A4 | |
| Pirenperone SCHEMBL10965711 | 0.93 | HTR2C (0.98) | CYP2D6HTR2CKDM4ETSHRCYP3A4 | |
| Pirenperone SCHEMBL10970070 | 0.91 | HTR2C (0.93) | CYP2D6HTR2CKDM4ETSHRCYP3A4 | |
| Pirenperone SCHEMBL10967003 | 0.91 | HTR2C (0.93) | CYP2D6HTR2CKDM4ETSHRCYP3A4 | |
| SCHEMBL10967011 | 0.89 | CYP2D6 (0.86) | CYP2D6HTR2CKDM4ETSHRCYP3A4 | |
| SCHEMBL17532707 | 0.87 | CYP2D6 (0.86) | CYP2D6HTR2CKDM4ETSHRCYP3A4 | |
| SCHEMBL6527939 | 0.82 | HTR2C (0.77) | CYP2D6HTR2CKDM4ETSHRCYP3A4 | |
| Metrenperone SCHEMBL2109868 | 0.82 | HTR2C (0.77) | CYP2D6HTR2CKDM4ETSHRCYP3A4 | |
| SCHEMBL6523807 | 0.81 | ACHE (0.71) | CYP2D6HTR2CKDM4ETSHRCYP3A4 | |
| SCHEMBL6522324 | 0.81 | HTR2C (0.76) | CYP2D6HTR2CKDM4ETSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4342870-A | SEROTONIN ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-08-03 | — | — | US | disclosed |