Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553255 | 0.90 | KMT2A (0.54) | LMNAKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL5395547 | 0.87 | ALDH1A1 (0.56) | LMNAKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL546987 | 0.87 | MEN1 (0.49) | KMT2AMEN1SIGMAR1 | |
| SCHEMBL13962938 | 0.84 | MEN1 (0.56) | LMNAPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL13962943 | 0.81 | MEN1 (0.46) | LMNAPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL13962874 | 0.80 | SIGMAR1 (0.54) | LMNAKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL13962841 | 0.79 | CHRM2 (0.51) | LMNAKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL13962854 | 0.77 | MEN1 (0.55) | LMNAKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL10967944 | 0.75 | HTT (0.54) | POLBKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2079886 | 0.75 | CHRNB2 (0.42) | LMNAKMT2AMEN1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0037265-B1 | 3-(1-PIPERIDINYLALKYL)-4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-01-23 | — | — | EP | disclosed |
| US-4342870-A | SEROTONIN ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-08-03 | — | — | US | disclosed |
| EP-0037265-A1 | 3-(1-piperidinylalkyl)-4H-pyrido(1,2-a)pyrimidin-4-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-10-07 | — | — | EP | disclosed |