Sugi Predict

Sugi Predict / Compounds / SCHEMBL1096952

SCHEMBL1096952

SCHEMBL1096952

COC(=O)c1cc(F)c(F)c(F)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.59
▸ POLB P06746 2/20 0.59
▸ L3MBTL1 Q9Y468 2/20 0.59
▸ XDH P47989 2/20 0.59
▸ TDP1 Q9NUW8 2/20 0.59
▸ LMNA P02545 2/20 0.59
▸ GAA P10253 1/20 0.59
▸ NFKB1 P19838 1/20 0.59
▸ GFER P55789 1/20 0.59
▸ NFKB2 Q00653 1/20 0.59
▸ RELA Q04206 1/20 0.59
▸ FUT7 Q11130 1/20 0.59
▸ CES2 O00748 2/20 0.56
▸ CES1 P23141 2/20 0.56
▸ CA1 P00915 4/20 0.56
▸ CA2 P00918 4/20 0.56
▸ CA12 O43570 3/20 0.56
▸ CA7 P43166 3/20 0.56
▸ CA9 Q16790 3/20 0.56
▸ CA14 Q9ULX7 3/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21712059 0.88 KDM4E (0.52) KDM4EPOLBL3MBTL1XDHTDP1
SCHEMBL1726759 0.86 KDM4E (0.50) KDM4EPOLBL3MBTL1XDHTDP1
SCHEMBL30273152 0.86 KDM4E (0.51) KDM4EPOLBL3MBTL1XDHTDP1
SCHEMBL30164563 0.86 KDM4E (0.50) KDM4EPOLBL3MBTL1XDHTDP1
SCHEMBL1727263 0.86 KDM4E (0.51) KDM4EPOLBL3MBTL1XDHTDP1
SCHEMBL23025106 0.86 KDM4E (0.50) KDM4EPOLBL3MBTL1XDHTDP1
SCHEMBL13189770 0.86 KDM4E (0.50) KDM4EPOLBL3MBTL1XDHTDP1
SCHEMBL28767906 0.85 KDM4E (0.48) KDM4EPOLBL3MBTL1XDHTDP1
SCHEMBL18306466 0.84 HDAC1 (0.59) KDM4EPOLBL3MBTL1XDHTDP1
SCHEMBL522695 0.84 KDM4E (0.57) KDM4EPOLBL3MBTL1XDHTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118993958-A Method for synthesizing polyfluoroaryl sulfide 三峡大学 2024-11-22 — — CN claimed
CN-122070277-A Androgen receptor PROTAC 葛兰素史密斯克莱知识产权发展有限公司 2026-05-19 — — CN disclosed
US-12577231-B2 Androgen receptor PROTACS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2026-03-17 — — US disclosed
US-12559506-B2 Indazole based compounds and associated methods of use ARVINAS OPERATIONS, INC. (US) 2026-02-24 — — US disclosed
US-20260001865-A1 ANDROGEN RECEPTOR PROTACS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2026-01-01 — — US disclosed
EP-4634169-A1 3-FLUORO-4-HYDROXYBENZMIDE-CONTAINING INHIBITORS AND/OR DEGRADERS AND USES THEREOF Pfizer Inc. (US) 2025-10-22 — — EP disclosed
EP-4598908-A1 HSD17B13 INHIBITORS AND/OR DEGRADERS Pfizer Inc. (US) 2025-08-13 — — EP disclosed
WO-2025072437-A1 HETEROARYL COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS ALPHINA THERAPEUTICS, INC. (US) 2025-04-03 — — WO disclosed
WO-2025061906-A1 ANDROGEN RECEPTOR PROTACS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2025-03-27 — — WO disclosed
CN-118993958-A Method for synthesizing polyfluoroaryl sulfide 三峡大学 2024-11-22 — — CN disclosed
EP-2338935-A1 FLUORINE-CONTAINING COPOLYMER COMPOSITION AND PROCESS FOR PRODUCTION THEREOF ASAHI GLASS COMPANY, LIMITED (JP) 2011-06-29 — — EP disclosed
WO-2010065674-A1 INHIBITORS OF HCV NS5A PRESIDIO PHARMACEUTICALS, INC. (US) 2010-06-10 — — WO disclosed
EP-2187893-A2 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS Anacor Pharmaceuticals, Inc. (US) 2010-05-26 — — EP disclosed
US-20100029687-A1 PIPERIDINE DERIVATIVE OR SALT THEREOF ASTELLAS PHARMA INC. (JP) 2010-02-04 — — US disclosed
US-20090291917-A1 Boron-Containing Small Molecules as Anti-Inflammatory Agents ANACOR PHARMACEUTICALS, INC. (US) 2009-11-26 — — US disclosed
WO-2009111676-A2 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS ANACOR PHARMACEUTICALS, INC (US) 2009-09-11 — — WO disclosed
US-7585886-B2 Pyrrolidine derivative or salt thereof ASTELLAS PHARMA INC. (JP) 2009-09-08 — — US disclosed
EP-2085383-A1 PIPERIDINE DERIVATIVES OR SALTS THEREOF Astellas Pharma Inc. (JP) 2009-08-05 — — EP disclosed
US-20090062366-A1 Pyrrolidine derivative or salt thereof ASTELLAS PHARAMA INC. (JP) 2009-03-05 — — US disclosed
EP-1882684-A1 PYRROLIDINE DERIVATIVE OR SALT THEREOF Astellas Pharma Inc. (JP) 2008-01-30 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090062366-A1 Pyrrolidine derivative or salt thereof CASR, CYP2R1, PTH1R KDM4E 2755/4885POLB 2422/4885L3MBTL1 3456/4885
US-12559506-B2 Indazole based compounds and associated methods of use LRRK2, CRBN, CLK2 KDM4E 988/4885POLB 4422/4885L3MBTL1 1200/4885
US-20090291917-A1 Boron-Containing Small Molecules as Anti-Inflammatory Agents NFKBIA, LITAF, CD68 KDM4E 4296/4885POLB 1963/4885L3MBTL1 2758/4885
US-20260001865-A1 ANDROGEN RECEPTOR PROTACS AR, CRBN, PSMA3 KDM4E 1036/4885POLB 3911/4885L3MBTL1 3601/4885
US-12577231-B2 Androgen receptor PROTACS AR, CRBN, PSMA3 KDM4E 1036/4885POLB 3911/4885L3MBTL1 3601/4885
US-20100029687-A1 PIPERIDINE DERIVATIVE OR SALT THEREOF CASR, CYP2R1, HCAR1 KDM4E 2417/4885POLB 2905/4885L3MBTL1 2226/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.