SCHEMBL109703

SCHEMBL109703

O=[N+]([O-])c1ccccc1Nc1ccc(O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 1.00
MEN1 O00255 7/20 1.00
KMT2A Q03164 7/20 1.00
GAA P10253 6/20 1.00
MAPK1 P28482 5/20 1.00
TDP1 Q9NUW8 5/20 1.00
PKM P14618 1/20 1.00
ALDH1A1 P00352 6/20 0.74
L3MBTL1 Q9Y468 3/20 0.74
CASP7 P55210 1/20 0.74
EPAS1 Q99814 1/20 0.52
POLB P06746 2/20 0.51
KDM4E B2RXH2 1/20 0.51
GFER P55789 1/20 0.51
ATM Q13315 1/20 0.51
HCAR3 P49019 1/20 0.51
LMNA P02545 2/20 0.51
RECQL P46063 1/20 0.51
MAPK13 O15264 1/20 0.49
MAPK12 P53778 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11528602 0.91 MAPT (0.83) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL11506844 0.91 ALDH1A1 (0.89) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL11507400 0.86 ALDH1A1 (0.79) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL230292 0.85 TDP1 (1.00) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL31333098 0.85 TDP1 (1.00) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL27844608 0.85 MEN1 (0.74) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL5718635 0.84 MAPK1 (0.77) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL11676980 0.83 MAPK1 (0.74) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL338789 0.83 MAPK1 (0.74) MAPTMEN1KMT2AGAAMAPK1
SCHEMBL7395072 0.83 MAPK1 (0.74) MAPTMEN1KMT2AGAAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3723864-B1 THICKENED ONE-COMPONENT HAIR TONER HENKEL AG & CO KGAA (DE) 2026-01-14 EP claimed
WO-2025061335-A1 METHOD FOR DYEING KERATIN FIBRES, COMPRISING THE APPLICATION OF AN OXIDATIVE PRE-TREATMENT AGENT AND A DYE COMPRISING DIRECT DYES HENKEL AG & CO. KGAA (DE) 2025-03-27 WO claimed
US-20240350386-A1 Hair Coloring Compositions Comprising Hydroxyalkyl Amines As Alkalising Agents WELLA GERMANY GMBH (DE) 2024-10-24 US claimed
CN-117222397-A Granular hair dyeing composition 威娜德国有限责任公司 2023-12-12 CN claimed
US-20230225952-A1 ADDITIVES FOR COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. 2023-07-20 US claimed
WO-2023017035-A1 HAIR COLORING COMPOSITIONS COMPRISING HYDROXYALKYL AMINES AS ALKALISING AGENTS WELLA GERMANY GMBH (DE) 2023-02-16 WO claimed
EP-4076353-A1 TINTING CONDITIONER HAVING IMPROVED DYEING PERFORMANCE Henkel AG & Co. KGaA (DE) 2022-10-26 EP claimed
US-11351100-B2 Hair coloring agent composition SUNNYPLACE CO., LTD. (JP) 2022-06-07 US claimed
EP-3989920-A1 ADDITIVES FOR COLORING AGENTS AND METHODS OF USE THEREOF Living Proof, Inc. (US) 2022-05-04 EP claimed
CN-114246807-A Acidic hair dye composition 朋友株式会社 2022-03-29 CN claimed
EP-0646108-B1 HYDROXYPROPYLATED 2-NITRO-P-PHENYLENEDIAMINES, PREPARATION METHOD THEREFOR AND USE THEREOF FOR DYEING KERATIN FIBRES OREAL (FR) 1998-10-14 EP claimed
EP-0646109-B1 NOVEL HYDROXYETHYLATED 2-NITRO-P-PHENYLENEDIAMINES AND USE THEREOF FOR DYEING KERATIN FIBRES OREAL (FR) 1997-09-03 EP claimed
EP-0673926-B1 2-Nitro-p-phenylenediamines having a sulfur atom in position 5, process for their preparation, dye compositions containing them and their use for dyeing keratinic fibres OREAL (FR) 1997-04-09 EP claimed
US-5516942-A DIRECT DYES FOR HAIR FOR YELLOW OR PURPLE L'OREAL (FR) 1996-05-14 US claimed
EP-0673926-A1 2-Nitro-p-phenylenediamines having a sulfur atom in position 5, process for their preparation, dye compositions containing them and their use for dyeing keratinic fibres L'OREAL (FR) 1995-09-27 EP claimed
EP-0646108-A1 HYDROXYPROPYLATED 2-NITRO-P-PHENYLENEDIAMINES, PREPARATION METHOD THEREFOR AND USE THEREOF FOR DYEING KERATIN FIBRES L'OREAL (FR) 1995-04-05 EP claimed
EP-0646109-A1 NOVEL HYDROXYETHYLATED 2-NITRO-P-PHENYLENEDIAMINES AND USE THEREOF FOR DYEING KERATIN FIBRES. OREAL (FR) 1995-04-05 EP claimed
WO-1994000414-A1 HYDROXYPROPYLATED 2-NITRO-P-PHENYLENEDIAMINES, PREPARATION METHOD THEREFOR AND USE THEREOF FOR DYEING KERATIN FIBRES L'OREAL (FR) 1994-01-06 WO claimed
WO-1994000415-A1 NOVEL HYDROXYETHYLATED 2-NITRO-P-PHENYLENEDIAMINES AND USE THEREOF FOR DYEING KERATIN FIBRES L'OREAL (FR) 1994-01-06 WO claimed
US-3950127-A HAIR DYE COMPOSITIONS CONTAINING NITRODIPHENYLAMINE DYES AND METHOD FOR DYEING HAIR THEREWITH CLAIROL INCORPORATED (US) 1976-04-13 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240350386-A1 Hair Coloring Compositions Comprising Hydroxyalkyl Amines As Alkalising Agents TYR, OGG1, UNG MAPT 1644/4885MEN1 4441/4885KMT2A 995/4885
US-20230225952-A1 ADDITIVES FOR COLORING AGENTS AND METHODS OF USE THEREOF COXFA4L2, TYR, OAT MAPT 1993/4885MEN1 3502/4885KMT2A 1779/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.