Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.57 |
| ▸ | HTR1B | P28222 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 8/20 | 0.54 |
| ▸ | DRD1 | P21728 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 6/20 | 0.51 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443673 | 0.91 | DRD2 (0.59) | HTR1DHTR1BDRD2DRD1DRD3 | |
| SCHEMBL8887664 | 0.91 | HTR1D (0.66) | HTR1DHTR1BDRD2DRD3HTR1A | |
| SCHEMBL7443661 | 0.81 | DRD2 (0.49) | HTR1DHTR1BDRD2DRD1DRD3 | |
| SCHEMBL7443670 | 0.81 | DRD2 (0.49) | HTR1DHTR1BDRD2DRD1DRD3 | |
| SCHEMBL8132500 | 0.81 | DRD2 (0.54) | HTR1DHTR1BDRD2DRD1DRD3 | |
| SCHEMBL8317195 | 0.81 | HTR1D (0.59) | HTR1DHTR1BDRD2DRD3 | |
| SCHEMBL7437400 | 0.78 | FYN (0.43) | HTR1DHTR1BDRD2DRD1DRD3 | |
| SCHEMBL7442666 | 0.76 | HTR1D (0.62) | HTR1DHTR1BDRD2DRD1DRD3 | |
| SCHEMBL7297810 | 0.76 | DRD2 (0.56) | HTR1DHTR1BDRD2DRD1DRD3 | |
| SCHEMBL7297821 | 0.76 | DRD2 (0.56) | HTR1DHTR1BDRD2DRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055043-B1 | 6,7,8,9-TETRAHYDRO-3H-BENZ(E)INDOLAMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND INTERMEDIATES USED THEREIN, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE INDOLAMINE DERIVATIVES | AYERST, MCKENNA AND HARRISON INC. (CA) | 1985-01-23 | — | — | EP | disclosed |
| US-4454150-A | 6,7,8,9-Tetrahydro-3H-benz(e)indol-7-amines and a method of dopamine receptor stimulation therewith | AYERST, MCKENNA & HARRISON INC. (US) | 1984-06-12 | — | — | US | disclosed |
| EP-0055043-A2 | 6,7,8,9-Tetrahydro-3H-benz(e)indolamine derivatives, processes for their preparation and intermediates used therein, and pharmaceutical compositions containing the indolamine derivatives | AYERST, MCKENNA AND HARRISON INC. (CA) | 1982-06-30 | — | — | EP | disclosed |