Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.49 |
| ▸ | DRD3 | P35462 | 8/20 | 0.49 |
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 4/20 | 0.38 |
| ▸ | DRD1 | P21728 | 4/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443661 | 1.00 | DRD2 (0.49) | DRD2DRD3HTR1AHTR7HTR1D | |
| SCHEMBL10972719 | 0.81 | HTR1D (0.57) | DRD2DRD3HTR1AHTR7HTR1D | |
| SCHEMBL7443673 | 0.80 | DRD2 (0.59) | DRD2DRD3HTR1AHTR7HTR1D | |
| SCHEMBL7436223 | 0.76 | HTR1D (0.56) | DRD2DRD3HTR1AHTR7HTR1D | |
| SCHEMBL7436227 | 0.76 | HTR1D (0.56) | DRD2DRD3HTR1AHTR7HTR1D | |
| SCHEMBL28997280 | 0.74 | DRD2 (0.67) | DRD2DRD3HTR1ADRD4 | |
| SCHEMBL28997283 | 0.74 | DRD2 (0.67) | DRD2DRD3HTR1ADRD4 | |
| SCHEMBL30335277 | 0.74 | DRD2 (0.67) | DRD2DRD3HTR1ADRD4 | |
| SCHEMBL28997284 | 0.74 | DRD2 (0.67) | DRD2DRD3HTR1ADRD4 | |
| SCHEMBL8887664 | 0.73 | HTR1D (0.66) | DRD2DRD3HTR1AHTR7HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |